From somatic mutationto incurable neurological disorders
We seek to understand how brain cells that acquire somatic mutations evolve into disease, and how to reverse that course — using multi-omic approaches in human brain tissue and animal models.
About the lab
Translational
Neurogenetics
Our laboratory studies how somatic mutations that arise in the brain drive a range of neurological disorders, including brain tumors, epilepsy and neurodegenerative diseases. To investigate this, we combine genetic and multi-omic analysis of human brain tissue with animal and organoid models. Our ultimate goal is not only to understand the origin and evolution of these diseases, but also to translate that understanding into therapeutic strategies that can reverse their course.
To this end, we are recruiting postdoctoral researchers, graduate students and research staff who want to join us in this work.
Since
2012
Established at KAIST GSMSE
Members
13
PI, postdocs, graduate students and research staff
Publications
80
Science, Nature, Nature Medicine, Neuron and others
Selected publications
All publications- IDH-mutant gliomas arise from glial progenitor cells harboring the initial driver mutation
- Precancerous Cells Initiate Glioblastoma Evolution and Contribute to Intratumoral Heterogeneity
- Brain somatic mutations observed in Alzheimer's disease associated with aging and dysregulation of tau phosphorylation
- BRAF somatic mutation contributes to intrinsic epileptogenicity in pediatric brain tumors
- Human glioblastoma arises from subventricular zone cells with low-level driver mutations
- Brain somatic mutations in MTOR disrupt neuronal ciliogenesis leading to focal cortical dyslamination
- Brain somatic mutations in MTOR cause focal cortical dysplasia type II leading to intractable epilepsy
- De novo somatic mutations in components of the PI3K-AKT3-mTOR pathway cause hemimegalencephaly